ARTICLE
Voltammetric assay of Guaifenesin in pharmaceutical formulation
- Journal of pharmaceutical and biomedical analysis
Discipline :
Non spécifiée
Auteur(s) :
I. TAPSOBA
Auteur(s) tagués :
TAPSOBA Issa
Renseignée par : TAPSOBA Issa
Résumé
The electrochemical oxidation of Guaifenesin in a pharmaceutical formulation containing Guaifenesin has been carried out in Britton–Robinson buffer (BRB)(0.04 mol L− 1) on platinum electrode. Guaifenesin exhibits a well-defined irreversible oxidation peak at 0.924 V/ref. The influence of pH on the oxidation of Guaifenesin was studied in BRB (pH range 2-5). A method for the analysis of Guaifenesin in BRB (0.04 mol L− 1, pH 2), which allows quantification over the range 20–60 μg mL− 1, was proposed and successfully applied to the determination of Guaifenesin in syrup with mean recovery and relative standard deviation of 103.3% and 1.32%, respectively.
Mots-clés
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