KIR2DL2, KIR2DL5A and KIR2DL5B Genes Induce Susceptibility to Dengue Virus Infection, while KIR3DL3 and KIR2DS5 Confer Protection.
- Mediterr J Hematol Infect Dis. , 14 (1) : 175-183
Résumé
BACKGROUND AND OBJECTIVES: Dengue fever (DF), an emerging and re-emerging viral
disease, is a major public health problem. The aim of this study was to
investigate the influence of KIRs genes polymorphism and KIRs genotypes in
susceptibility to dengue virus infection and disease severity in a population
from Burkina Faso through a case-control study.
METHODS: KIRs genes determination was performed using PCR-SSP in 50 patients
infected by dengue virus (DENV) and 54 Healthy controls (HC) subjects who had
never been infected.
RESULTS: Data analysis showed significant association between frequencies of
three KIR genes and dengue virus infection (DF): KIR2DL2 (OR: 7.32; IC:
2.87-18.65; P
Mots-clés
Burkina Faso; Dengue infection; Haplotype; KIRs genes; SSP-PCR